Who are we?
Precision Medicine in Dermatology.
In order to achieve this we will require a much deeper understanding about the different factors that contribute to the course of disease between patients with the same disease such as:
Environmental. Genetic. Molecular.
Our current research projects aim at developing technologies that should enable us to adress these questions, resulting in solutions that can one day support treatment decisions.
News from the hub
Innovation is on the agenda for most of big corporations. Executives are aware innovation should be in the DNA of the organization in order to be competitive, survive the long game and most importantly bring the best in class solutions to customers. However, a traditional corporate infrastructure can often be a double-edged sword for innovations – while it provides the necessary financial resources and support for groundbreaking ideas, the ever-growing corporate structure and its bureaucracy could hinder development of breakthrough projects.
To overcome such challenges, LEO Pharma established the LEO Science & Tech Hub and it has been set up to operate in a unique fashion that could be seen as independent yet well integrated with different research units within LEO Pharma.
It’s been close to two years since the LEO Science & Tech Hub established itself in Cambridge, USA. Since then, we’ve launched new projects, expanded our reputation and developed a number of notable partnerships and collaborations within the Greater Boston and New York areas. We’ve done so by fully embracing the mission and model on which the LEO Science & Tech Hub was founded: to foster innovation, support great ideas and identify technologies that enable LEO Pharma to build a precision medicine platform within dermatology. So far, our journey towards this goal has taught us quite a bit, and we’d like to share some of what we’ve learned:
- Innovation is a mindset rather than an organizational design
Domain expertise, talented employees and a supportive organizational structure are all great assets for an innovation unit. But what we have discovered is that many other elements are arguably more important for your organization’s success. For example, at the hub we have made the conscious effort to champion open and free dialogue, transparency, willingness to take risks and accountability. Our team truly values the culture of addressing what we like to call the “elephant in the room.” More specifically, we are all encouraged to speak up regarding potential problems found in our day-to-day processes so that we can constantly work to improve upon them. We instill this mindset in every member of our team, regardless of hierarchy or title.
- Capabilities and competencies
Build a team where you have the best people on board – the doers. The capabilities and competencies in the team need to complement each other. We like to think of our team as a commando-like team where every team member has his or her unique specialty or competency and at the same time are able to lead discussions outside their specialty. This creates a scenario where an individual is comfortable covering for his or her colleague when necessary. One way to achieve this is by creating a working environment where knowledge sharing is of high priority.
- Keep your decision-making team small and report higher in the organization
Remember that your innovation department is external-facing, therefore make your collaborative partnerships a priority. Agility and the ability to make quick decisions is crucial to ensuring success, thus reporting higher in the organization helps you avoid bureaucracy and unneeded governance boards. At the hub, our team members are empowered to make decisions and at the same time we’ve kept our decision-making team small, which has streamlined processes including flexible budgets and that has made a big difference overall.
- Putting “Skin” in the game
Our mindset has become very much centered around what value we can bring to our potential partners as opposed to what’s in it for us, and this has made all the difference. In fact, it has been one of the most critical learnings for the Hub and has enabled us to build meaningful relationships with external partners. This way of thinking implies a commitment to long-term growth as opposed to just immediate success. Our team feels a sense of empowerment when we spend quality time and resources helping start-ups and external partners within the local ecosystem achieve their own goals. We trust the process and recognize that this type of work will be well worth it in the long run.
- Collaborations should be based on high scientific integrity and transparency
We strive to ensure that partners and potential collaborators benefit from meetings with our team. This means that solid preparation must take place beforehand. Aim to deliver high-quality input to the individual or group sitting across the table from you, but don’t be afraid to admit where you lack knowledge or don’t know. Partnerships in this field are most often born from a mutual passion for the science behind it all, so make sure that this is your focus. Discussions around legal and ownership matters can wait. When those conversations do come about, consider flexible collaboration models that suit all stakeholders.
- Connect and integrate with internal research/business units
At the hub, we love the quote, “If you want to go fast, go alone. If you want to go far, go together.” This sentiment is important, especially for innovation units, as they are often expected to be flexible with regards to their working model. While you definitely want to maintain a certain level of flexibility, it is important to stay integrated with your internal business units. Most innovation projects, if successful, will need to be fully integrated into the organization at some point, so it is key to ensure your internal ambassadors are tied in and informed. Secondly, you have a wealth of internal expertise that should be plugged in whenever necessary; remember, the innovation unit and the other units are in this journey together. To make it easier, create a working model where people from other business units can come and spend quality time at your office to get inspired and visualize opportunities that otherwise would have been missed.
- It is ok to ask for help within your network
One of the most beneficial aspects of joining the ecosystem in Boston (and the U.S for that matter) is that a lot of people know someone who could potentially have the required capabilities or competencies to impact initiatives. People here understand the importance of networking, especially those who are trying to develop innovative products and solutions. Don’t be afraid to ask for help but be aware of the local business culture e.g. response time for emails etc. If your approach is both targeted and respectful, you’ll be surprised at how many relevant connections you can make.
- The special sauce
Even if the above steps and roadmaps are followed, none of this would be possible without a great vision and leadership. Remember innovation units are built with a focus on spotting future opportunities and in a dynamic world like today where disruption comes from the outside e.g. Uber and taxis, Airbnb and hotel industries and in order to maneuver in such an environment, one would need the courage and strength to explore the unknown. So hand the responsibilities of leading such initiatives to individuals who are able to envision a future for your organization and at the same time are able to take their colleagues on a journey towards that vision.
LEO Science & Tech Hub, the Boston based R&D unit of LEO Pharma, has entered into a collaboration with Dina Katabi and MIT’s Computer Science and Artificial Intelligence Laboratory (CSAIL). Together they will explore the potential of the MIT group’s Emerald system to quantify scratching behavior. The Emerald technology uses the reflection of radio signals to measure human activity such as gait, breathing and sleep quality.
“The Emerald system includes new machine learning algorithms that analyze the radio signals in the environment in order to recognize movement patterns,” said Dina Katabi, PhD and Professor of Computer Science at MIT. “The more you teach it, the greater its ability to recognize different patterns. We believe it has the potential to measure the scratching habits of patients and recognize patterns that may be easily missed by other systems.”
Itch is a severe co-morbidity in many dermatological diseases, especially atopic dermatitis (eczema) and often leads to a vicious cycle of scratching and further inflammation. Itching impacts quality of life and is often associated with negative effects on cognitive functioning. Atopic dermatitis affects between 9% – 18% of all children and 3% of adults.
Development of new drugs to combat itch is hampered by the lack of a quantifiable measure. Currently, itch is rated by the patient on a scale from 1-10 and is entirely subjective. If the Emerald system can quantify scratching, it could lead to the validation of a new standard of measurement for itch to be used as an end-point in clinical trials.
“After seeing Dina present data on the Emerald system, it immediately spurred the idea that this could be used to help improve clinical trial design in dermatology,” said Troels Marstand, Chief Data Scientist at LEO Science and Tech Hub. “This project shows that innovation in pharma can come from unexpected places and reinforces the need to look beyond your own area of expertise for potential solutions.”
The LEO Science & Tech Hub is recognized for its unique collaborative approach of seeking cutting-edge technology for dermatological applications. Within the first year of its launch, the Hub has successfully formed multiple collaborations to explore minimally invasive biomarker technologies, drug delivery technology, and advanced imaging technology with leading research institutes and biotechnology companies including The Karp Lab, Novopyxis, Elektrofi and The Wellman Center for Photomedicine at Massachusetts General Hospital.
Dina Katabi’s research covers a broad range of topics related to wireless systems and digital health. Her work is characterized by a rare combination of building and deploying practical systems, coupled with rigorous formal analysis. Her CSAIL group is focused on developing novel sensing technologies and Internet-of-things solutions. Recent developments include the Emerald system, a modified WIFI router capable of reading the radio signals that bounce off people’s bodies and using them to measure human motion and vital signs.
About LEO Science & Tech Hub
The LEO Science & Tech Hub is a R&D innovation unit of LEO Pharma dedicated to identifying, developing, and funding innovative solutions that improve the lives of people with skin diseases. It was founded in 2016 as a catalyst to transform early-stage innovations into solutions for improving the lives of people with skin diseases. We collaborate, explore cutting-edge ideas and make investments. We are an agile group of scientific experts with an entrepreneurial mindset and a vision of how to give patients control over disease by predicting, diagnosing, and monitoring conditions. The LEO Science & Tech Hub is based in Cambridge, Mass. For more information, please visit www.leo-scitech.com, or connect with us at email@example.com or on Twitter @LEOscitech.