Who are we?
Precision Medicine in Dermatology.
In order to achieve this we will require a much deeper understanding about the different factors that contribute to the course of disease between patients with the same disease such as: Environmental. Genetic. Molecular. Our current research projects aim at developing technologies that should enable us to adress these questions, resulting in solutions that can one day support treatment decisions.
News from the hub
In a new partnership, the LEO Science & Tech Hub and Venture Café Tokyo share a core aim – to bolster a flourishing life sciences ecosystem in Japan.
With its mission of “connecting innovators to make things happen,” Venture Café Tokyo works to connect innovators through attractive spaces, programs and stories. Venture Café Tokyo reaches an ecosystem that spans entrepreneurs, new business development, investors, educators and policymakers. It is an open community.
The cluster program will regularly invite innovators at the forefront of selected science and healthcare areas during Thursday discussion sessions, open to the community and looking to the future. These sessions will feature experts and thought-leaders seeking possible ways to overcome barriers to innovation and drive greater opportunity within Japanese life sciences.
“We are truly excited to sponsor and partner with Venture Café Tokyo on this cluster program, which we hope will grow and expand,” says Tord Labuda, Ph.D. Vice President, Research and Development, Asia-Pacific Hub, LEO Pharma. “I am really impressed with how they are driving innovation by creating a positive, collaborative atmosphere thriving with opportunities.”
“It is clear that Japan has high standards for science and technology, however we need greater translation of basic research into real-world solutions – a need where start-ups may be able to play a significant role,” says Taruho Kuroda, Director, LEO Science & Tech Hub, Japan, who is helping coordinate the partnership. “In recent years, the life sciences start-up scene in Japan has become more and more active and seen as an attractive market for venture investment.”
By activating the Japanese life sciences scene, more innovations have the potential to be translated into medical solutions helping patients, Taruho adds.
The LEO Science & Tech Hub sees its role as a catalyst connecting dots as well as this being a way to raise visibility of the company and its innovation ecosystem within Japan. The partnership also introduces the company to active innovators in Tokyo, Japan and beyond.
“We are so excited to partner with LEO Science & Tech Hub to launch our life science cluster program at Venture Café Tokyo,” says Yasuhiro Yamakawa, Ph.D. Executive Director, Venture Café Tokyo, and Associate Professor of Entrepreneurship, Babson College. “Combining LEO Pharma’s strong leadership in the field of dermatology and our expanding global network, currently in 11 cities across 6 countries, we hope to innovate together to better the world. By connecting innovators to make things happen, we will.”
MAT-31450. January 2020.
— Partnership with the Boston-based R&D innovation unit of LEO Pharma A/S advances development of Epicore Biosystems’ wearable Discovery patch and electrochemical sensors to measure prognostic skin health, inflammation biomarkers —
— Proof-of-principle study in atopic dermatitis patients seeks to track inflammatory biomarkers across different skin locations, will be conducted at Northwestern University’s Feinberg School of Medicine to establish baselines –
Nov. 7, 2019, CAMBRIDGE, Mass. – LEO Science & Tech Hub, the Boston-based R&D innovation unit of LEO Pharma A/S, announced today the next phase of a research collaboration in atopic dermatitis (AD) with Epicore Biosystems, a wearable microfluidics and biosensor spinout from Northwestern University’s Center for Bio-Integrated Electronics.
The partnership advances the development of Epicore’s wearable Discovery patch and electrochemical sensors to measure prognostic skin health and inflammation biomarkers. The goal is to explore if and how these biochemical markers can apply to and inform treatment decisions and therapeutic targets.
Phase II of the collaboration will involve a proof-of-principle study in AD patients to track inflammatory biomarkers across different skin locations. The study will be conducted in the Department of Dermatology at Northwestern University’s Feinberg School of Medicine to establish baselines. The partnership will also leverage Epicore’s connected electrochemical-sensing solutions toward characterization of skin health and disease-specific biomarkers in real-time and outside confines of a clinic.
“Real-time assessment of inflammatory biomarkers found in sweat and interstitial fluid push the boundaries, leading to objective assessment of interventions for people affected by AD as well as across other chronic diseases,” said Dr. Roozbeh Ghaffari, co-founder and Chief Executive Officer of Epicore Biosystems.
“This collaboration between Epicore and LEO Science & Tech Hub represents a unique opportunity to collect data to enable research in translational medicine on the link between cytokines in sweat and disease state of atopic dermatitis patients,” said Michael Sierra, Vice President, LEO Science & Tech Hub. “Non-invasive technologies have the potential to deepen unique disease understanding, paving the way for precision medicine within dermatology.”
An initial study was completed in June 2019 in collaboration with Northwestern dermatologists to establish baseline data using the Discovery platform and to test its clinical utility. The team demonstrated the ability to quantify the concentrations of target cytokines in sweat across different skin locations. This serves as a foundation for the phase II effort in AD patients.
“We’re looking forward to engaging with both Epicore Biosystems and LEO Science & Tech Hub in evaluating the Discovery patch in patients with atopic dermatitis. Our experiences so far with the Discovery patch has been overwhelmingly positive,” said Dr. Steve Xu, Department of Dermatology Assistant Professor at Northwestern University’s Feinberg School of Medicine. “Sweat is the next frontier for biomarker discovery – I believe that there will be unique signatures that will open new avenues for early intervention and precision therapy in atopic dermatitis.”
“Our collaboration with LEO Science & Tech Hub to deploy the Discovery patch in clinical studies serves as the benchmark, helping bring this platform closer to reality in dermatology and skin microbiome research,” said Jeffrey Model, co-Founder and Chief Product Officer of Epicore Biosystems.
Since its launch, the LEO Science & Tech Hub has successfully formed multiple collaborations to explore minimally invasive biomarker technologies, drug-delivery devices, advanced imaging systems and remote monitoring methods with leading research institutes and biotechnology companies including MIT, The Karp Lab, Elektrofi and The Wellman Center for Photomedicine at Massachusetts General Hospital.
About Epicore Biosystems
Epicore Biosystems is a spinout company from Professor John Rogers’ Laboratory at Northwestern University’s Center for Bio-Integrated Electronics and Simpson-Querrey Institute for Bio/Nanotechnology. Epicore Biosystems is developing skin-like wearable fluidic sensors to be capable of non-invasively measuring metabolic and digital biomarkers in real-time. The company has established partnerships with Fortune 100 companies, the Department of Defense, and research hospitals to drive personalized care with their wearable fluidic products. For more information, please visit EpicoreBiosystems.com or @EpicoreBio on Twitter.
About LEO Science & Tech Hub
The LEO Science & Tech Hub is an R&D innovation unit of LEO Pharma A/S dedicated to identifying, developing, and funding innovative solutions that improve the lives of people with skin diseases. It was founded in 2016 as a catalyst to transform early-stage innovations into solutions for improving the lives of people with skin diseases. We collaborate, explore cutting-edge ideas and make investments. We are an agile group of scientific experts with an entrepreneurial mindset and a vision of how to give patients control over disease by predicting, diagnosing, and monitoring conditions. The LEO Science & Tech Hub is based in Cambridge, Mass. For more information, please visit www.leo-scitech.com, or connect with us at firstname.lastname@example.org, on Twitter @LEOscitech or LinkedIn.
About LEO Pharma
LEO Pharma A/S helps people achieve healthy skin. The company is a leader in medical dermatology with a robust R&D pipeline, a wide range of therapies and a pioneering spirit. Founded in 1908 and owned by the LEO Foundation, LEO Pharma has devoted decades of research and development to advance the science of dermatology, setting new standards of care for people with skin conditions. LEO Pharma is headquartered in Denmark with a global team of 6,000 people, serving 76 million patients in 130 countries. In 2018, the company generated net sales of DKK 10,410 million.
Rhonda Sciarra, LEO Science & Tech Hub
AJ Aranyosi, PhD, Epicore Biosystems